Objectives: To evaluate the role of antibiotic prophylaxis in general surgery with the incidence of wound infection and in comparison with extended regimen antibiotics. Methods: A prospective study of 150 patients were enrolled and operated upon electively which are divided into 2 groups. 100 patients were taking prophylactic antibiotics and 50 patients were on extended antibiotic regimen. Questionnaires concerning age, sex, type of surgery, complications and parameters of antibiotic prophylaxis (antibiotic choice, route, dose, timing of first dose and duration of prophylaxis) were completed. Results: Patients with prophylactic antibiotic, 79% of patients underwent a clean surgical operation and 21% underwent a clean contaminated operation. Inguinal hernia and open cholecystectomy were the commonest operation in each category, 4% of this group developing wound infection, also we take comparison with 50 cases in which we use extended antibiotic regimen Laparoscopic cholecystectomy and Para umbilical hernia were the commonest operations in this category, 6% of this group developing wound infection Ampicillin and cefotaxime were the most frequently prescribed antibiotics (50%, 50% respectively). All the 100 patients were received the antibiotic on time. Conclusions: This study found that the use of pre-operative prophylactic antibiotics does have a statistically significant effect on postoperative infection rates in surgical management.

ackground: Intestinal anastomosis is one of the most commonly performed procedure it required to reestablish gastrointestinal continuity after surgical resection, traumatic disruption or bypass procedures. In last decade, advances in intestinal stapling devices have led to an increased frequency of stapled anastomosis. There are a variety of proposed benefit from a stapled technique: better blood supply, reduced tissue manipulation, less oedema, uniformity of suture, adequate or perhaps wider, lumen at the site of anastomosis, ease and rapidity. Objectives: To compare the relative safety and effectiveness of stapled anastomosis with that of hand sewn anastomosis for large bowel surgery. Patients & Methods: A prospective study was conducted on 103 patients who suffered from benign and malignant disease in addition to trauma patients. They were divided into two groups (SA) group which involved (51) patients where the anastomosis were done by stapler and other group of (52) patients where the anastomosis were done by hand sewing named as (HS) group. All elective cases were prepared for surgery preoperatively by mechanical and chemical preparation while patients in emergency situation had the full criteria for primary anastomosis. Both groups had the same preoperative characters such as age and sex, and the types of outcome analyzed were specific mortality, clinical anastomotic leak, stricture, anastomotic haemorrhage, re-operation, wound infection, anastomotic duration and hospital stay. Results: A total of 9 patients (17.6%) in SA group developed complications compared to 20 patients (38.5%) in HS group (P. value> 0.019 …