English العربية کوردی

Dr. Mohammed Abdulwahid Hami

Assistant Professor
College of Science / Department of Chemistry
009647514019034
mohammed.hami@uoz.edu.krd
Number of Publications: 10
0
Awards
10
Published Journal Articles
2
Thesis
1
Training Course

0
Book Chapter
0
Conference
0
Presentation
0
Workshop
2020
Doctor of Philosophy

Department of CHemistry
University of Zakho

2013
Master

Faculty of Natural Sciences
Keele University

2011
Bachelor

Chemistry Department
University of Duhok

2011

Kurdistan Chemists Syndicate

Member

2011-09-01,current
Assistant Professor

Date: 2023-04-01

Lecturer

Date: 2017-01-01

2025

Effect of waterpipe smoking and its cessation on metabolic biomarkers and a novel biomarker omentin-1
Biomarkers (Issue : 1) (Volume : 23)
Background and Objective Waterpipe smoking (WPS) has increased globally and may lead to various metabolic disorders. However, its long-term effects and cessation impact on metabolic biomarkers and omentin-1 remain unclear. This study aims to evaluate the impact of WPS and its cessation on metabolic biomarkers and omentin-1 levels and explore their correlations. Materials and Methods 90 individuals were categorized into three groups (non-smokers, waterpipe smokers and cessation of waterpipe smokers). FBS and lipid profiles including TC, TG and HDL were measured using the Cobas 6000 c501 system, while FI was analyzed with the Cobas 6000 c601 system. Omentin-1 concentrations were determined using the enzyme-linked immunosorbent assay (ELISA) with a human omentin ELISA kit. Results FI, HOMA-IR and lipid profiles were significantly elevated in WPS and cessation groups. Omentin-1 and DBP levels significantly decreased in both groups compared to non-smokers. Increased WPS duration leads to reduced BMI, WC and DBP, while cessation duration decreases FBS and SBP. A negative association was identified among omentin-1 with FBS and O2. Conclusion WPS and its cessation adversely affect metabolic health, reducing omentin-1 levels and increasing the risk of metabolic disorders. Over time, cessation improves specific biochemical markers, highlighting the need for public health awareness.
2025-03

2024

DEVELOPING AND VALIDATING A STABILITY-INDICATING UV-VIS NANODROP 2000C METHOD FOR THE SIMULTANEOUS DETERMINATION OF THE ANTI-HYPERTENSIVE DRUG HYDROCHLOROTHIAZIDE (HCTZ) IN BOTH BULK AND TABLET DOSAGE FORMS
Science Journal of University of Zakho (Issue : 3) (Volume : 12)
For the simultaneous determination of anti-hypertensive drugs Hydrochlorothiazide (HCTZ) in bulk and tablet dosage forms, a simple, specific, accurate, and precise stability-indicating UV-Vis Nanodrop 2000c method was developed and validated. The maximum absorption of Hydrochlorothiazide was revealed at 271 nm using methanol as a solvent. The validation results showed good linearity (R2 = 0.9997) within the concentration range of 10-50µg/mL. The RSD revealed an acceptable value (less than 0.6 percent) in the precision study at three levels. 1.01 and 3.3g µg/mL were found to represent the LOD and LOQ, respectively. Locally and commercial tablets are Available Drug Products. Accuracy at three levels showed good recovery, more than 99% percent. The proposed method was used to analyse the stability of local and commercial tablets. The stability of their pharmaceuticals was investigated under acidic, oxidative, thermal, alkaline, and photolytic conditions in this research. In accordance with the guidelines set by the International Council for Harmonisation (ICH), the method was effectively validated. Subsequently, the validated method was employed to analyze commercially available pharmaceutical dosage forms
2024-08

2023

Diagnostic values and trace element status in prediabetes and diabetes mellitus
Clinical Nutrition Open Science (Issue : 52) (Volume : 52)
Summary Background There are many undiagnosed cases of pre-diabetes and diabetes worldwide. Having a variety of biomarkers for screening and diagnosing diabetes mellitus has a significant positive impact. Objectives To investigate whether mineral elements, their ratios, testosterone and ferritin can detect pre-diabetes and diabetes mellitus. Materials and methods In this study, 120 volunteers were included. The volunteers were divided into three groups (control, pre-diabetes and diabetes mellitus). For all volunteers, HbA1c (measured by automated analyses), serum zinc (Zn), serum copper (Cu) (measured by colorimetric method), ferritin, testosterone and serum iron (Fe) (measured by electrochemiluminescence immunoassay) were measured. Results The ratio of Zinc/Iron in both pre-diabetes and diabetes mellitus is significantly different from those of control group (P-value <0.05). In addition, the receiver operating characteristic curve analysis showed that the ratio Zn/Fe can accurately detect pre-diabetes and diabetes (Area under the curve (AUC)= 1 for male pre-diabetic group, 0.8 for female pre-diabetic group, 0.85 for male diabetic and 0.88 for female diabetic group). The level of serum Cu increases in both pre-diabetes and diabetic group. But the elevation is significant only for pre-diabetic group. Conclusion Zn/Fe can be used as a biomarker for screening and diagnosing pre-diabetes and diabetes mellitus.
2023-11

2022

Studying the Association Between Systolic Blood Pressure and Thyroid Stimulating Hormone in Newly Diagnosed Subclinical Hyperthyroidism Female Patients
Science Journal of University of Zakho (Issue : 4) (Volume : 10)
Background: Subclinical hyperthyroidism is a condition in which thyroid stimulating hormone (TSH) is mildly decreased with both free iodine thyroxine (free T4) and triiodothyronine (T3) within the normal range. The aim of this research is to determine the association between TSH with lipid profiles, age, blood pressure and body mass index (BMI) and also to evaluate lipid profiles in subclinical hyperthyroid patients. Materials and Methods: Ninety patients with subclinical hyperthyroidism were chosen as the patient group and 50 healthy individuals age-matched were chosen as the control group. Thyroid function tests TSH, T4 and T3 were performed by VIDAS and on the same day lipid profiles were performed by (Biolis 24i Premium) in the laboratory of General Zakho Hospital, Kurdistan Region, Iraq. Results: In subclinical hyperthyroidism the BMI and diastolic blood pressure values were non-significantly low (P=0.13 and p=0.27 respectively) whereas systolic blood pressure increased slightly but was still non-significant. TSH was significantly and negatively related to systolic blood pressure. Conclusion: Lipid profiles and systolic and diastolic blood pressure are not altered in subclinical hyperthyroidism. However, systolic blood pressure is related to the severity of the decrease in TSH levels.
2022-10
The relationship between thyroid hormones and lipid profile in subclinical hypothyroidism female patients
Baghdad Journal of Biochemistry and Applied Biological Sciences (Issue : 3) (Volume : 3)
Background and objectives: Subclinical thyroid disorder is a most common subclinical disease among many medical conditions such as cardiovascular disease and subclinical Lyme disease. The aim of this study was to determine the relationship between lipid profile results, lipid ratios, and anthropometric parameters and thyroid hormones. Methods: One hundred patients (ages 20 to 50 years) with subclinical hypothyroidism (SHT group) and 50 healthy subjects (control group), who are age-matched with patients, were included in the current study. Thyroid function tests (TSH, T 3 and T 4) were determined by immunodiagnostic assay system (VIDAS) for all participants. The serum glucose and lipid profile tests parameters were evaluated by Biolis 24i Premium chemistry analyser. In addition, systolic and diastolic blood pressure were measured for each individual in the study using mercury sphygmomanometer. Results: The levels of high-density lipoprotein-cholesterol (HDL-c) were significantly lower in the SHT group when compared with control group. Whereas, the level of low-density lipoprotein-cholesterol (LDL-c), the ratios total cholesterol (TC)/HDL-c and LDL-c/HDL-c were significantly higher in SHT group than in controls. Moreover, TSH was negatively correlated with diastolic blood pressure. Conclusions: Both LDL-c and HDL-c are altered in subclinical hypothyroidism patients. And, there is a negative association between TSH and diastolic blood pressure.
2022-09

2021

Increased oxidative stress and alterations in the levels of some trace elements and minerals in obese/overweight subjects
Trace Elements and Electrolytes (Issue : 4) (Volume : 38)
Abstract. Introduction: Reactive oxygen species are considered to be important intracellular signaling molecules. However, these molecules, together with obesity, are risk factors for cardiovascular and metabolic diseases. This research attempts to explore the links among oxidative stress, trace elements, and obesity. Materials and methods: 160 male individuals were involved in this study. Six oxidative stress parameters were measured via enzyme-linked immunosorbent assay kits; glutathione, catalase, 8-isoprostaglandin, malondialdehyde, vitamin C, and vitamin E. Trace elements were determined via flame atomic absorption spectrometry. Results: Significant differences in the levels of (calcium (p = 0.0097), magnesium (p = 0.0005), copper (p = 0.0015), zinc (p = 0.0187), glutathione (p = 0.0276), catalase (p = 0.0329), 8-iso-prostaglandin (p = 0.0330), malondialdehyde (p = 0.0127), and vitamin C (p = 0.0263)) among healthy, overweight, and obese groups. Furthermore, significant positive correlations were found between calcium, magnesium, and iron with most oxidative stress parameters. Conclusion: Oxidative stress is increased in obesity, and elevation in the levels of some trace elements increases oxidative stress. In addition, calcium, magnesium, and zinc are significantly decreased in populations with obesity, whereas serum copper was significantly increased in the obese group.
2021-07
The association between selected elements and body mass index and age in male subjects
Trace Elements and Electrolytes (Issue : 3) (Volume : 37)
The number of obese people is increasing at a frightening rate around the globe. Metals play crucial roles in virtually all body functions, in particular in lipid metabolism. In this study, we investigate the association between calcium, magnesium, copper, iron, zinc, and manganese and body mass index (BMI) and age. In this study, 160 male individuals were enrolled. The subjects were divided into three groups based on body mass index (healthy BMI = 18.5 – 24.9, overweight BMI = 25 – 29.9, and obese ≥ 30 BMI. Each group was subdivided into two subgroups based on age: 18 – 39 years and 40 – 60 years. The elements were measured using flame atomic absorption spectrometry. The level of serum magnesium and zinc were significantly lower in the obese group (p = 0.0002, 0.0189, respectively), whereas serum copper was significantly higher in the obese group (p = 0.0019). The age factor had a significant effect on the data of serum iron and magnesium (p = 0.0019, 0.0006, respectively). There are significant associations between BMI and the elements; magnesium, zinc, and copper. In addition, age affects the levels of serum iron and magnesium.
2021-03

2016

The Levels of Some Trace Elements and Correlations between them in Non-Insulin Dependent Diabetes Mellitus
Indian Journal Of Natural Sciences (Issue : 38) (Volume : 7)
Trace elements are known to play vital roles in both metabolism and growth of living cells. The aims of this study are to investigate the levels of some trace elements (cupper, iron, nickel and zinc) in diabetic patients and studying the correlation between them. 50 healthy volunteers and 200 diabetic subjects were included in the study. Trace elements were measured via flame atomic absorption spectroscopy (Perkin Elmer). In addition, fasting blood sugar, serum urea and serum creatinine were measured via glucose oxidase, urease method and Jaffe method respectively. Except serum cupper, all the three other trace elements were significantly lower in diabetic groups. Age and gender did not have any relationships with the levels of trace elements. All the trace elements did not correlate with each other apart from cupper with both iron and nickel. These results do not confirm that low levels of trace elements causes diabetes mellitus. Further studies are needed to show the relationships.
2016-10
The Status of Serum Zinc, Magnesium and Calcium in Type 2 Diabetic Patients and Their Correlation with Renal Function
Journal of University of Zakho (Issue : 2) (Volume : 4)
Trace elements play significant roles in the metabolism of insulin. The aim of this study is to investigate the level of serum zinc, magnesium and calcium in type 2 diabetes mellitus and relate them with the functionality of kidneys. 200 diabetic individuals and 50 healthy controls were enrolled. For each individual, blood sugar, serum urea and serum creatinine were determined. In addition, serum zinc, magnesium and calcium were determined for each individual via flame atomic absorption spectrometry. Significant differences were found in the level of serum zinc and magnesium between diabetic and healthy control groups. However, there was not any difference in the level of serum calcium between the two groups. It is not certain whether the low level of serum zinc and magnesium cause diabetes or they are the consequence of development of diabetes. The level of serum trace elements did not correlate with the functions of kidneys.
2016-06
Influence of HCV on Electrolyte and some Liver Parameters in Chronic Renal Failure Patients on Hemodialysis in Erbil Governorate
Indian Journal Of Natural Sciences (Issue : 36) (Volume : 6)
The present study aims to measure the electrolyte and some liver parameters in chronic renal failure patients infected with HCV and non-HCV infected. This study comprised 75 patients with chronic renal failure on hemodialysis, (15) of them tested positive for HCV by ELISA test. Patients were divided into two groups (HCV-positive and HCV-negative).The data of the current study was expressed as (Mean ± S.E.M) and the SPSS using samples T-test for comparing between pre and post hemodialysis for both HCV-positive and HCV-negative patients. P value(P<0.05)level was considered to be statistically significant.The results showed a significant increase in serum potassium, ALT and AST and nonsignificant increase in sodium in HCV-positive patients as compared to HCV-negative patients in prehemodialysis and post hemodialysis patients. Furthermore, non-significant decrease in calcium in HCVpositive patients as compared to HCV-negative patients in pre-hemodialysis and post hemodialysis patients. Hepatitis C virus affected on serum transaminase activity (ALT and AST) in chronic renal failure patients on hemodialysis. Chronic renal failure patients infected with HCV on hemodialysis have higher level potassium as compared to non-infected HCV patients.
2016-06

2017

Oxidative Stress and Biochemical Parameters in Obese Individuals
Introduction: The number of obese people is increasing at frightening rate in the globe. Metals play crucial roles in lipid metabolism, thus it may have possible relation with obesity. Reactive oxygen species together with obesity are risk factors of cardiovascular and metabolic diseases. In the current study we investigate the association between calcium, magnesium, copper, iron, zinc and manganese with body mass index (BMI) and age. We are also trying to explore the links among oxidative stress, trace elements and obesity. Methods: In this study160 male individuals were enrolled. The subjects were divided into three groups based on their body mass index (healthy BMI=18.5-24.9, overweight BMI= 25-29.9 and obese ≥30 BMI. Each group was subdivided into two groups based on age (18-39) yrs and (40-60) yrs. Lipid profile and uric acid were determined using enzymatic methods. Albumin was measured using bromcresol green dye, whereas total bilirubin was measured using colorimetric test by coupling total bilirubin with diazonium ion. The elements were measured using flame atomic absorption spectrometry. Six oxidative stress parameters were measured using enzyme-linked immunosorbent assay kits; Glutathione, Catalase, 8-iso-prostaglandin, Malondialdehyde, Vitamin C, Vitamin E. Results: The level of serum magnesium and zinc were significantly lower in the obese group (p value= 0.0002, 0.0189 respectively). Whereas serum copper was significantly higher in the obese group (p value= 0.0019). The age factor has significant effect on serum iron and magnesium (p value= 0.0019, 0.0006 respectively). Significant differences in the levels of calcium (p= 0.0097), magnesium (p = 0.0005), copper (p = 0.0015), zinc (p= 0.0187), glutathione (p= 0.0276), catalase (p= 0.0329), 8-iso-prostaglandin (p= 0.0330), malondialdehyde (p= 0.0127) and vitamin C (p= 0.0263)) among healthy, overweight and obese groups. Furthermore, significant positive correlations were found between calcium, magnesium and iron with most oxidative stress parameters. Conclusion: There are significant associations between BMI and the elements; magnesium, zinc and copper. In addition, age does affect the levels of serum iron and magnesium. Oxidative stress is increased in obesity and elevated levels of trace elements increases oxidative stress. In addition, calcium, magnesium and zinc are significantly decreased in population with obesity, whereas serum copper was significantly increased in obese group.
2017-10-01

2012

Sulphation of polysacchrides and correlation with anticoagulant activities
Polysacchrides
2012-01-01

2013

Teaching methodology
Teaching methodology
2013-10-01,2013-12-01