2024-04

JACC: Cardiovascular Imaging

Population aging is one of the most important demographic transformations of our time. Increasing the “health span”—the proportion of life spent in good health—is a global priority. Biological aging comprises molecular and cellular modifications over many years, which culminate in gradual physiological decline across multiple organ systems and predispose to age-related illnesses. Cardiovascular disease is a major cause of ill health and premature death in older people. The rate at which biological aging occurs varies across individuals of the same age and is influenced by a wide range of genetic and environmental exposures. The authors review the hallmarks of biological cardiovascular aging and their capture using imaging and other noninvasive techniques and examine how this information may be used to understand aging trajectories, with the aim of guiding individual- and population-level interventions to promote healthy aging.

2024-04

JACC: Cardiovascular Imaging

Background The absence of population-stratified cardiovascular magnetic resonance (CMR) reference ranges from large cohorts is a major shortcoming for clinical care. Objectives This paper provides age-, sex-, and ethnicity-specific CMR reference ranges for atrial and ventricular metrics from the Healthy Hearts Consortium, an international collaborative comprising 9,088 CMR studies from verified healthy individuals, covering the complete adult age spectrum across both sexes, and with the highest ethnic diversity reported to date. Methods CMR studies were analyzed using certified software with batch processing capability (cvi42, version 5.14 prototype, Circle Cardiovascular Imaging) by 2 expert readers. Three segmentation methods (smooth, papillary, anatomic) were used to contour the endocardial and epicardial borders of the ventricles and atria from long- and short-axis cine series. Clinically established ventricular and atrial metrics were extracted and stratified by age, sex, and ethnicity. Variations by segmentation method, scanner vendor, and magnet strength were examined. Reference ranges are reported as 95% prediction intervals. Results The sample included 4,452 (49.0%) men and 4,636 (51.0%) women with average age of 61.1 ± 12.9 years (range: 18-83 years). Among these, 7,424 (81.7%) were from White, 510 (5.6%) South Asian, 478 (5.3%) mixed/other, 341 (3.7%) Black, and 335 (3.7%) Chinese ethnicities. Images were acquired using 1.5-T (n = 8,779; 96.6%) and 3.0-T (n = 309; 3.4%) scanners from Siemens (n = 8,299; 91.3%), Philips (n = 498; 5.5%), and GE (n = 291, 3.2%). Conclusions This work represents a resource with healthy CMR-derived volumetric reference ranges ready for clinical implementation.

2024-02

Journal of the American Heart Association (القضية : 3) (الحجم : 13)

BACKGROUNDExisting research demonstrates the association of shorter leukocyte telomere length with increased risk of age‐related health outcomes including cardiovascular diseases. However, the direct causality of these relationships has not been definitively established. Cardiovascular aging at an organ level may be captured using image‐derived phenotypes of cardiac anatomy and function. METHODS AND RESULTSIn the current study, we use 2‐sample Mendelian randomization to assess the causal link between leukocyte telomere length and 54 cardiac magnetic resonance imaging measures representing structure and function across the 4 cardiac chambers. Genetically predicted shorter leukocyte telomere length was causally linked to smaller ventricular cavity sizes including left ventricular end‐systolic volume, left ventricular end‐diastolic volume, lower left ventricular mass, and pulmonary artery. The association with left ventricular mass (β =0.217, Pfalse discovery rate=0.016) remained significant after multiple testing adjustment, whereas other associations were attenuated. CONCLUSIONSOur findings support a causal role for shorter leukocyte telomere length and faster cardiac aging, with the most prominent relationship with left ventricular mass.

2018-08

International Journal of Advanced Computer Science and Applications (القضية : 8) (الحجم : 9)

As the use of technology is increasing rapidly, the amount of shared, sent, and received information is also increas-ing in the same way. As a result, this necessitates the need for finding techniques that can save and secure the information over the net. There are many methods that have been used to protect the information such as hiding information and encryption. In this study, we propose a new encryption method making use of amino acid and DNA sequences. In addition, several criteria including data size, key size and the probability of cracking are used to evaluate the proposed method. The results show that the performance of the proposed method is better than many common encryption methods, such as RSA in terms of evaluation criteria.

2016-09

European Scientific Journal, ESJ (القضية : 27) (الحجم : 12)

XML files are used widely to save the information especially in the field of bioinformatics about the whole genome. There are many programming languages and modules used to parse XML files in different platforms such as Linux, Macintosh and Windows. The aim of this report is to reveal and determine which common programming language to use and on which platform is better to parse XML files in terms of memory usage, CPU time consumption and executing time.

2016-05

European Scientific Journal, ESJ (القضية : 15) (الحجم : 12)

The process involve in building a successful website goes beyond knowing web developing languages such as HTML and CSS. The success or failure of any website depends heavily on the use of some aspects of Graphical User Interface. These aspects are usually reserved for client’s wishes and desires. The content features of the GUI are used to stay in touch with visitors. Therefore, this article will highlight some important GUI features used in building an attractive and a successful website.