2017-05-30

Breast cancer is the most common cancer among women. A key factor in tumor development is evasion of immune detection therefore, the search for alternative medicines with reduced toxicity towards normal tissues as well as ability to improve function of immune system and targets tumors cells has received growing interest.Ganoderma lucidum have been demonstrated to possess anti-tumor and immunomodulatory activities. Although numerous studies on the immunomodulatory effects of Ganoderma lucidum have been reported, little is known regarding its immunomodulatory effects in breast cancer patients when given with chemotherapeutic agents. This study aim to investigate the immunomodulating effects of Ganoderma lucidum on breast cancer patients when administered with different chemotherapy through measuring the serum levels of the biomarkers; interferon-γ (IFN-γ), tumor necrotic factor-α (TNF-α), inteleukin-8 (IL-8), and adiponectin (ADN).