Lina Yousif Mohammed

الاطاريح

2014

Studies on daunorubicin and actinorhodin type II polyketide synthase, PhD thesis

2014-01-06

Daunorubicin (DNR) and its C-14 hydroxlated derivative doxorubicin (DOX) are important anticancer chemotherapy drugs used for the treatment of acute myeloid leukaemia and breast cancer. Although the structural, regulatory and resistance genes of the DNR/DOX biosynthetic clusters have been identified, their functions characterized and a general scheme for the biosynthetic pathway has been proposed, little is known about the structural organization of these enzymes within the PKS and how this affects catalysis.

1996

Esterases of monocytes in malignancy biochemical and cytochemical studies

1996-09-02

A study of the esterases of monocyte inpatients with malignant disorders was carried out. The work included biochemical and cytochemical investigation.