Due to the limited information available regarding the effect of Omeprazole (OM) on rats liver function. This study aimed to elucidate the impact on liver morphology, hepatic enzymes, liver weight, and electrolytes in male Wistar rats.
Fifty rats were randomly allocated into five groups (n= 10): control, OM (5 mg/kg/day), OM + Vit. E (5 mg/kg/day cach), Vit. E alone (5 mg/kg/day cach), and a recovery group (5 mg/kg/day cach), for 28 days. Biochemical analysis evaluated hepatic enzymes (ALP, AST, ALT) and serum electrolytes. Histological examination of hepatic tissues was performed using H&E, PAS, and Masson's Trichrome staining. OM significantly increased ALP (177.56 U/L), AST (145.2 U/L), and ALT (47.8 U/L) compared with controls (P≤0.05). Co-administration of Vit E effectively attenuated these elevations, while the recovery group demonstrated only partial normalization. OM also significantly reduced liver weight, altered liver shape, and disrupted Cl, Ca , and K" homeostasis, though Na* levels remained unaffected. On a histological basis,
blood vessels and sinusoids were dilated with blood. around the central vein, increased collagen deposition, and decreased glycogen granules in hepatocytes were observed; OM induced notable parenchymal changes, whereas Vit. E preserved near-normal hepatic architecture. The hepatic somatic index showed no significant variation across groups (P> 0.05). The liver was harmed by omeprazole, and vitaminE prevented the effects.
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