2026-07

Molecular Histology (Issue : 218) (Volume : 57)

Due to the limited information available regarding the effect of Omeprazole (OM) on rats liver function. This study aimed to elucidate the impact on liver morphology, hepatic enzymes, liver weight, and electrolytes in male Wistar rats. Fifty rats were randomly allocated into five groups (n= 10): control, OM (5 mg/kg/day), OM + Vit. E (5 mg/kg/day cach), Vit. E alone (5 mg/kg/day cach), and a recovery group (5 mg/kg/day cach), for 28 days. Biochemical analysis evaluated hepatic enzymes (ALP, AST, ALT) and serum electrolytes. Histological examination of hepatic tissues was performed using H&E, PAS, and Masson's Trichrome staining. OM significantly increased ALP (177.56 U/L), AST (145.2 U/L), and ALT (47.8 U/L) compared with controls (P≤0.05). Co-administration of Vit E effectively attenuated these elevations, while the recovery group demonstrated only partial normalization. OM also significantly reduced liver weight, altered liver shape, and disrupted Cl, Ca , and K" homeostasis, though Na* levels remained unaffected. On a histological basis, blood vessels and sinusoids were dilated with blood. around the central vein, increased collagen deposition, and decreased glycogen granules in hepatocytes were observed; OM induced notable parenchymal changes, whereas Vit. E preserved near-normal hepatic architecture. The hepatic somatic index showed no significant variation across groups (P> 0.05). The liver was harmed by omeprazole, and vitaminE prevented the effects.

2022-04

http://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/889 (Issue : 2) (Volume : 10)

Abstract This study aimed to evaluate how genistein affected the weight and histological structure of the thymus gland in adult and postnatal (P22) female albino mice. Fifteen adult female albino mice and fifteen postnatal (P22) female albino mice were used and divided between two experiments. The animals were divided into three groups (n=5) in each experiment: Group (I), the control group, Group (II), and Group (III), which received 10mg and 50mg genistein/ kg B. W. respectively. In comparison to the control, treatment with 50mg genistein resulted in a significant increase in the weight of the thymus gland in both adult and postnatal mice. When compared to control, treatment with 10mg genistein resulted in a significant increase in this weight in adult females and a significant decrease in the weight of this gland in postnatal mice. Both genistein concentrations had a negative impact on the gland’s histological features. The formation of a "Starry sky" in cortical and medullary regions, an increase in the thickness of regions due to an increase or decrease in the number of T cells depending on genistein concentration, as well as histiocyte hyperplasia and blood vessel congestion, are among these consequences. In conclusion, because genistein affects thymic tissue negatively, it has the potential to create thymic and immunological diseases.