2017-10-01

Introduction: The number of obese people is increasing at frightening rate in the globe. Metals play crucial roles in lipid metabolism, thus it may have possible relation with obesity. Reactive oxygen species together with obesity are risk factors of cardiovascular and metabolic diseases. In the current study we investigate the association between calcium, magnesium, copper, iron, zinc and manganese with body mass index (BMI) and age. We are also trying to explore the links among oxidative stress, trace elements and obesity. Methods: In this study160 male individuals were enrolled. The subjects were divided into three groups based on their body mass index (healthy BMI=18.5-24.9, overweight BMI= 25-29.9 and obese ≥30 BMI. Each group was subdivided into two groups based on age (18-39) yrs and (40-60) yrs. Lipid profile and uric acid were determined using enzymatic methods. Albumin was measured using bromcresol green dye, whereas total bilirubin was measured using colorimetric test by coupling total bilirubin with diazonium ion. The elements were measured using flame atomic absorption spectrometry. Six oxidative stress parameters were measured using enzyme-linked immunosorbent assay kits; Glutathione, Catalase, 8-iso-prostaglandin, Malondialdehyde, Vitamin C, Vitamin E. Results: The level of serum magnesium and zinc were significantly lower in the obese group (p value= 0.0002, 0.0189 respectively). Whereas serum copper was significantly higher in the obese group (p value= 0.0019). The age factor has significant effect on serum iron and magnesium (p value= 0.0019, 0.0006 respectively). Significant differences in the levels of calcium (p= 0.0097), magnesium (p = 0.0005), copper (p = 0.0015), zinc (p= 0.0187), glutathione (p= 0.0276), catalase (p= 0.0329), 8-iso-prostaglandin (p= 0.0330), malondialdehyde (p= 0.0127) and vitamin C (p= 0.0263)) among healthy, overweight and obese groups. Furthermore, significant positive correlations were found between calcium, magnesium and iron with most oxidative stress parameters. Conclusion: There are significant associations between BMI and the elements; magnesium, zinc and copper. In addition, age does affect the levels of serum iron and magnesium. Oxidative stress is increased in obesity and elevated levels of trace elements increases oxidative stress. In addition, calcium, magnesium and zinc are significantly decreased in population with obesity, whereas serum copper was significantly increased in obese group.

2012-01-01

Polysacchrides