English العربية کوردی

ئەز   Adar Salim Saeed

Assist lecturer

Specialties

Clinical medicine

Adar.saeed@uoz.edu.krd
07504428241
Iraq , Zakho
0
Awards
4
Published Journal Articles
2
Thesis
2
Training Course

0
Book Chapter
10
Conference
0
Presentation
0
Workshop

Education

Ph.D. in Clinical Medicine

Conservative Medicine Division لە Semmelweis University

2025

M.Sc. in Medical Mycology

Department of Biology لە University of Duhok

2019

B.Sc. in Biology

University of Duhok لە University of Duhok

2013

Academic Title

Assist lecturer

2025-02-01

Assist research

2013-11-07

Published Journal Articles

International Journal of Molecular Sciences (Issue : 24) (Volume : 25)
Sigma-1 Receptor as a Novel Therapeutic Target in Diabetic Kidney Disease

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. Current treatments for... See more

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease. Current treatments for DKD do not halt renal injury progression, highlighting an urgent need for therapies targeting key disease mechanisms. Our previous studies demonstrated that activating the Sigma-1 receptor (S1R) with fluvoxamine (FLU) protects against acute kidney injury by inhibiting inflammation and ameliorating the effect of hypoxia. Based on these, we hypothesized that FLU might exert a similar protective effect in DKD. Diabetes was induced in male Wistar rats using streptozotocin, followed by a seven-week FLU treatment. Metabolic and renal parameters were assessed along with a histological analysis of glomerular damage and fibrosis. The effects of FLU on inflammation, hypoxia, and fibrosis were tested in human proximal tubular cells and normal rat kidney fibroblasts. FLU improved renal function and reduced glomerular damage and tubulointerstitial fibrosis. It also mitigated inflammation by reducing TLR4, IL6, and NFKB1 expressions and moderated the cellular response to tubular hypoxia. Additionally, FLU suppressed TGF-β1-induced fibrotic processes and fibroblast transformation. These findings suggest that S1R activation can slow DKD progression and protect renal function by modulating critical inflammatory, hypoxic, and fibrotic pathways; therefore, it might serve as a promising novel drug target for preventing DKD.

 2024-12
International Journal of Molecular Sciences (Issue : 23) (Volume : 24)
Cardioprotective and antifibrotic effects of low-dose renin–angiotensin–aldosterone system inhibitors in type 1 diabetic rat model

Diabetic cardiovascular complications are associated with up to 50% mortality, and current therapies are not... See more

Diabetic cardiovascular complications are associated with up to 50% mortality, and current therapies are not effective enough. Renin–angiotensin–aldosterone system inhibitors (RAASis) are the standard of care for diabetic patients with hypertension and albuminuria. Based on our previous studies reporting the renoprotective effects of low-dose RAASis, here, we hypothesized that low-dose RAASi treatment has cardioprotective and antifibrotic benefits in type 1 diabetes mellitus (T1DM). After five weeks of T1DM, adult male Wistar rats received low doses of ramipril, losartan, or eplerenone for two weeks. Heart rate, blood pressure, and pulse wave velocity (PWV) were recorded. Aortic intima–media thickness (IMT), collagen accumulation, and myocardial fibrosis were assessed. All RAASis reduced PWV elevation, prevented the progression of myocardial fibrosis, and normalized B-type natriuretic peptide, troponin I, and fibroblast growth factor 23 levels without affecting blood pressure. Interestingly, only eplerenone reversed the decline in Klotho levels and reduced IMT and fibrosis in the media of the aorta. Our comparative analysis suggests that mineralocorticoid receptor antagonists, particularly eplerenone, may offer superior efficacy in halting both the arterial and the myocardial injuries in T1DM compared to angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers.

 2023-12
PLOS ONE (Issue : 2) (Volume : 17)
SGLT2 inhibitor dapagliflozin prevents atherosclerotic and cardiac complications in experimental type 1 diabetes

ntroduction Cardiovascular disease (CVD) is two to five times more prevalent in diabetic patients and... See more

ntroduction Cardiovascular disease (CVD) is two to five times more prevalent in diabetic patients and is the leading cause of death. Therefore, identification of novel therapeutic strategies that reduce the risk of CVD is a research priority. Clinical trials showed that reduction in the relative risk of heart failure by sodium-glucose cotransporter 2 inhibitors (SGLT2i) are partly beyond their glucose lowering effects, however, the molecular mechanisms are still elusive. Here we investigated the role of SGLT2i dapagliflozin (DAPA) in the prevention of diabetes-induced cardiovascular complications. Methods Type 1 diabetes was induced with streptozotocin (65 mg/bwkg, ip.) in adult, male Wistar rats. Following the onset of diabetes rats were treated for six weeks with DAPA (1 mg/bwkg/day, po.). Results DAPA decreased blood glucose levels (D: 37±2.7 vs. D+DAPA: 18±5.6 mmol/L; p<0.05) and prevented metabolic decline. Aortic intima-media thickening was mitigated by DAPA. DAPA abolished cardiac hypertrophy, and myocardial damage. Cardiac inflammation and fibrosis were also moderated after DAPA treatment. Conclusions These data support the preventive and protective role of SGLT2i in diabetes-associated cardiovascular disease. SGLT2i may provide novel therapeutic strategy to hinder the development of cardiovascular diseases in type 1 diabetes, thereby improve the outcomes.

 2022-02
ZANCO Journal of Pure and Applied Sciences (Issue : 31) (Volume : 4)
Isolation, Identification and Antifungal Susceptibility Testing of Candida Species from Dermatologic Specimens in Duhok Province

Candida species. is a member of the mucous membrane of the normal flora, gastrointestinal tract... See more

Candida species. is a member of the mucous membrane of the normal flora, gastrointestinal tract and skin. They are endogenous opportunistic pathogens that cause secondary infections with underlying immunocompromised condition. Candidiasis is a common fungal infection in human. This study was aimed to isolation and identification of Candida using germ tube, chlamydospore formation, and chromogenic agar testes and to asses antifungal susceptibility to some isolates. A total of 180 samples of skin swabs and skin particles, nail and hair were collected from patients in Duhok Province Hospitals, outpatient and a number of private clinic dermatologists in Duhok city. A Total of 63 Candida isolates was detected in this study. These isolates were subjected to germ tube test, chlamydospores formation and inoculation on commercially available CHROMagar. Candida albicans was the main yeast species isolated followed by C. krusei, C. tropicalis and C. glabrata CHROMO agar is a convenient and very fast method of identifications of Candida species even in resources poor settings. The result of antifungal sensitivity test revealed that itraconazole is the main active antifungal against all Candi

 2019-09

Thesis

2024-12-09
Novel therapeutic strategies in diabetes-associated cardiovascular diseases.

Novel therapeutic strategies in diabetes-associated cardiovascular diseases.

 2024
2019-04-04
Isolation, Identification and Antifungal Susceptibility of Dermatophytes Isolated from Dermatophytosis Patients in Duhok Province/Kurdistan Region of Iraq

Isolation, Identification and Antifungal Susceptibility of Dermatophytes Isolated from Dermatophytosis Patients in Duhok Province/Kurdistan Region... See more

Isolation, Identification and Antifungal Susceptibility of Dermatophytes Isolated from Dermatophytosis Patients in Duhok Province/Kurdistan Region of Iraq

 2019

Conference

1st PhD Clinical Days
 2023-12
SGLT2 inhibitor dapagliflozin prevents atherosclerotic and cardiac complications in experimental type 1 diabetes

1st PhD Clinical Days (2023): „SGLT2 inhibitor dapagliflozin prevents atherosclerotic and cardiac complications in experimental type 1 diabetes”

American Diabetes Association
 2023-05
10-LB: Activation of Sigma-1 Receptor as a Novel Therapeutic Target in Diabetic Kidney Diosease

American Diabetes Association (2023): „10-LB: Activation of Sigma-1 Receptor as a Novel Therapeutic Target in Diabetic Kidney Diosease”

Semmelweis Symposium
 2022-09
SGLT2 Inhibitor Dapagliflozin Prevents Cardiovascular Complications in Experimental Type 1 Diabetes

Semmelweis Symposium (2022): „SGLT2 Inhibitor Dapagliflozin Prevents Cardiovascular Complications in Experimental Type 1 Diabetes”

Semmelweis PhD days
 2022-07
The Sigma 1 Receptor Mediated Role of 17β estradiol in in-vitro models of Renal Ischemia Reperfusion Injury

Semmelweis PhD days (2022): „The Sigma 1 Receptor Mediated Role of 17β estradiol in in-vitro models of Renal Ischemia Reperfusion Injury”

Nephrology Dialysis Transplantation
 2021-07
Antifibrotic effects of sglt2 inhibition in the kidney and proximal tubular cells”

Nephrology Dialysis Transplantation (2021): „Antifibrotic effects of sglt2 inhibition in the kidney and proximal tubular cells”

Experimental Biology
 2020-07
SGLT2 inhibitors are renoprotective via mitigation of tubular hypoxia and protein O-GlcNAcylation

Experimental Biology (2020): „SGLT2 inhibitors are renoprotective via mitigation of tubular hypoxia and protein O-GlcNAcylation”

57th ERA-EDTA Congress
 2020-07
Multi-organ damage following perinatal asphyxia in a rat model

57th ERA-EDTA Congress (2020): „Multi-organ damage following perinatal asphyxia in a rat model”

Experimental Biology
 2020-06
Sigma-1 receptor agonists are renoprotecticve in a rat model of kidney transplantation

Experimental Biology (2020): „Sigma-1 receptor agonists are renoprotecticve in a rat model of kidney transplantation”

International Conference on Clinical Research and Medical Science (ICCRAMS)
 2019-07
Isolation and identification of dematophytes from dermatological specimens in Duhok Province

International Conference on Clinical Research and Medical Science (ICCRAMS) (2019): „Isolation and identification of dematophytes from dermatological specimens in Duhok Province”

International engineering and natural science conference (IENSC)
 2019-04
Antifungal sensitivity of some dermatophytic fungi from Duhok Province/Kurdistan of Iraq

Antifungal

Training Course

2023-12-03,2023-12-08
Buisness in Health Care Innovation- from Research Idea to Market Product

Hosted by Semmelweis University and Harvard Medical School

 2023
2022-07-01,2025-07-18
Experimental Animals – Animal Experiments

Provide comprehensive knowledge of legal, ethical, and scientific aspects of animal experimentation. Covers study design, anesthesia, euthanasia, welfare standards, data analysis, and alternatives to animal use. it covers: Ethical and legal frameworks Experimental design &... See more

Provide comprehensive knowledge of legal, ethical, and scientific aspects of animal experimentation. Covers study design, anesthesia, euthanasia, welfare standards, data analysis, and alternatives to animal use. it covers: Ethical and legal frameworks Experimental design & statistics Anatomy, physiology, husbandry, hygiene Anesthesia, euthanasia, humane endpoints Transgenic animals, alternatives (the 3Rs)

 2022